Israeli Scientists Find Connection Between Celiac disease and Tooth Decay

Yael Gruper and Prof. Jakub Abramson (photo Weizmann Institute of Science)

Researchers from the Weizmann Institute of Science say they may have found a link between Celiac disease in children and sensitivity to a protein abundant in dairy products. This, they say, disrupts tooth enamel development.

The study by Prof. Jakub Abramson and his team at the Weizmann Institute of Science, published recently in Nature, may shed light on this problem by revealing a new children’s autoimmune disorder that hinders proper tooth enamel development. The disorder is common in people with a rare genetic syndrome and in children with celiac disease. These findings could help develop strategies for early detection and prevention of the disorder.

The Mayo Clinic explains that Celiac disease is an illness caused by an immune reaction to eating gluten. Gluten is a protein found in foods containing wheat, barley, or rye.

If you have celiac disease, eating gluten triggers an immune response to the gluten protein in your small intestine. Over time, this reaction damages your small intestine’s lining and prevents it from absorbing nutrients, a condition called malabsorption. Over time, this reaction damages your small intestine’s lining and prevents it from absorbing nutrients, a condition called malabsorption.

The intestinal damage often causes symptoms such as diarrhea, fatigue, weight loss, bloating, or anemia. It also can lead to serious complications if it is not managed or treated. In children, malabsorption can affect growth and development in addition to gastrointestinal symptoms.

There’s no definite cure for celiac disease, says the Mayo Clinic. But for most people, following a strict gluten-free diet can help manage symptoms and help the intestines heal.

Enamel, the hardest and most mineral-rich substance in the human body, covers and protects our teeth, explain the researchers. But in one of every 10 people – and in one third of children with celiac disease – this layer appears defective, failing to protect the teeth properly. As a result, teeth become more sensitive to heat, cold and sour food, and they may decay faster. In most cases, the cause of the faulty enamel production is unknown.

“Similarly to the lessons learned from gluten, we can assume that the consumption of large quantities of dairy products could lead to the production of antibodies against k-casein,” Abramson explains. “This protein increases the amount of cheese that can be produced from milk, so the dairy industry deliberately raises its concentration in cow’s milk. Our study, however, found that the milk k-casein is a potent immunogen, which may potentially trigger an immune response that can harm the body itself.”

In an attempt to understand how celiac disease, known to cause intestinal damage, may also cause damage to tooth enamel, the researchers first examined whether people with this disease have autoantibodies that attack the enamel. They found that a large proportion of celiac patients have these autoantibodies, just as do people with APS-1. But the “education” that takes place in the thymus gland of these patients seems normal, so why do they develop these antibodies? The researchers hypothesized that some proteins are found in both the intestine and the dental tissue and that these proteins play an important role in the development of tooth enamel. In this case, the antibodies that identify proteins in the intestine might move through the bloodstream to the dental tissue, where they could start to disrupt the enamel production process.

Tooth enamel flaws are common, not just among people with celiac disease or APS-1. “Many people suffer from impaired tooth enamel development for unknown reasons,” Abramson says. “It is possible that the new disorder we discovered, along with the possibility of diagnosing it in a blood or saliva test, will give their condition a name. Most importantly, early diagnosis in children may enable preventive treatment in the future.”