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gut microbiome May Hold the Cure for Autoimmune Disease

TAU study on treatment of Huntington's disease


Scientists from the University of Texas Health Science Center at Houston boast that they may have discovered a way to treat Autoimmune Diseases using gut bacteria found in the human body. Their study titled “Resetting microbiota by Lactobacillus reuteri inhibits T reg deficiency-induced autoimmunity via adenosine A2A receptors, ” was published online in The Journal of Experimental Medicine.

Gut microbiome, the bacteria that reside within the gastrointestinal tract which helps the body with all manner of activities from its immune system to digesting food could cause autoimmune diseases if it changes in certain ways.

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The study states that replacing the missing gut bacteria, or restoring a key metabolite called inosine, could help treat children with a rare and often fatal autoimmune disease called IPEX syndrome.

Bacteria from our digestive systems known as gut bacteria may be useful in treating many different health problems. The human body is filled with over 100 trillion bacteria which constitute 90% of what is in our systems.

B. infantis and L. reuteri, are strains which can help improve the immune system by attacking inflammation, which is a possible cause of depression. The microbes can also affect appetite, sending signals to the brain which tell you that you are full and not hungry anymore by increasing levels of the hormone leptin and suppressing ghrelin. So it could also become the wonder diet pill of the future.

“Our findings suggest that probiotic L. reuteri, inosine, or other A2A receptor agonists could be used therapeutically to control T cell-mediated autoimmunity, ” says Yuying Liu, an associate professor of pediatrics and gastroenterology at the University of Texas and the study’s lead author.



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