Connect with us

Hi, what are you looking for?

Jewish Business News

World News

Molecular Biology Revolutionized by Ben Gurion U Researchers

DNA patterns

Researchers at the Ben Gurion University in Beer Sheva have made a major breakthrough in the study of molecular biology. They have discovered the function of repetitive DNA patterns and what causes protein binding in a study conducted together with Duke University.

The new findings could even be used for cancer research.

Please help us out :
Will you offer us a hand? Every gift, regardless of size, fuels our future.
Your critical contribution enables us to maintain our independence from shareholders or wealthy owners, allowing us to keep up reporting without bias. It means we can continue to make Jewish Business News available to everyone.
You can support us for as little as $1 via PayPal at
Thank you.

Despite the fact that modern biotechnology makes it possible to determine the entire DNA sequence for each individual patient, the major part of such information is currently unusable due to the fact that the functional significance of over 95% of the DNA sequence is not understood. One of the most striking features of genomic DNA is that it contains numerous repetitive sequence patterns of unknown function. However, BGU researchers and their colleagues from Duke University have identified a possible function of such repetitive DNA patterns; they have discovered that these patterns enhance the binding of regulatory proteins to DNA.

There are four types of such nucleotide bases, abbreviated A, T, C, and G, and a genomic DNA molecule represents a long double-stranded chain composed of these nucleotides. Alterations in the sequence of a genomic DNA molecule, which are called mutations, are responsible for numerous genetic disorders in both children and adults.

Understanding molecular mechanisms of how regulatory proteins, called transcription factors, recognize their specific binding sites encoded into genomic DNA represents one of the central, long-standing problems of molecular biology.Until now, it has reasonably been assumed that specific base-pair recognition is the only mechanism controlling the specificity of transcription factor-DNA binding.

Contrary to this assumption, a series of experiments by Dr. David B. Lukatsky and Ariel Afek of BGU’s Department of Chemistry and Raluca Gordân, Joshua L. Schipper, and John Horton of the Center for Genomic and Computational Biology, Department of Biostatistics and Bioinformatics, Duke University, reported on the front cover of PNAS, demonstrate that a DNA context characterized by certain repetitive sequence patterns surrounding specific binding sites, significantly influences protein-DNA
binding specificity. In particular, the team measured the binding of the human regulatory protein c-Myc to genomic DNA.

This protein is involved in numerous human cancers. Their discovery shows that the presence of repetitive DNA patterns can alleviate the harmful effect of mutations on protein-DNA binding.

“We expect that our results will significantly impact the understanding of molecular, biophysical principles of transcriptional regulation, and significantly improve our ability to predict how variations in DNA sequences, i.e. mutations, influence gene expression programs in living cells, ” says Lukatsky.



You May Also Like

World News

In the 15th Nov 2015 edition of Israel’s good news, the highlights include:   ·         A new Israeli treatment brings hope to relapsed leukemia...


The Movie The Professional is what made Natalie Portman a Lolita.


After two decades without a rating system in Israel, at the end of 2012 an international tender for hotel rating was published.  Invited to place bids...

VC, Investments

You may not become a millionaire, but there is a lot to learn from George Soros.