Ozgene, a leading provider of genetically modified mice for medical research, has developed goGermline, a new technology to generate knockout and knock-in mice.
Online PR News – 20-August-2014 – Ozgene, a leading provider of genetically modified mice for medical research, has developed a new technology called goGermline. This technology produces genetically modified mice faster, more efficiently and with significantly fewer animals. As such, goGermline has a major positive impact on animal welfare within knockout and knock-in mouse model production. This new technology is part of Ozgenes overall mission to advance humanity – inspire curiosity.
Traditionally, genetic modification is done in mouse embryonic stem cells (ESC) from which a chimeric mouse is created. When mated, a percentage of the chimeric offspring are from the modified ESC that carry the genetic modification. However, this also inevitably produces mice that are not ESC derived and therefore unnecessary.
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goGermline technology addresses this issue by generating only the ESC offspring, with significantly less unnecessary mice being produced. goGermline has a number of benefits. From an animal welfare point of view it improves the three Rs (Replace, Reduce, Refine). From a researchers point of view it improves production timelines and efficiencies in making knockout and knock-in mouse models.
For more information regarding goGermline technology, please contact Ozgene by visiting www.ozgene.com/goGermline
About the company: Ozgene is a global provider of custom designed knockout, knock-in and transgenic mice, with a demonstrated track record of successful mouse model generation, specialising in C57BL/6 strain. Ozgene has over two decades of experience in the field, and more than 250 research papers have been published using Ozgene mice.
|Mr Eddie Noonan
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