Connect with us

Hi, what are you looking for?

Jewish Business News

Syndicated

Lars Hammarstrm to Speak at Cell Based Assay Conference, Oct. 7-8, 2014, Dublin

Lars Hammarstrm, Karolinska Institutet, to Speak at Cell Based Assay & Screening Technologies Conference, October 7-8, 2014 in Dublin, Ireland

Lars Hammarstrm, Karolinska Institutet, to Speak at Cell Based Assay & Screening Technologies Conference, October 7-8, 2014 in Dublin, Ireland

Online PR News – 08-July-2014 – Lars Hammarstrm will speak on Phenotypic Targeting of Acquired Vulnerabilities in Glioblastoma Multiforme at the Cell Based Assay & Screening Technologies Conference, to be held October 7-8, 2014 in Dublin, Ireland.

Glioblastoma multiforme (GBM) is the most aggressive of tumors that affect the CNS, and GBM patients have marginal life expectancy. Current treatment options are limited and tumor recurrence frequent, and due to the diverse genetic landscape of gliomas, the success of targeted therapies focusing on specific tumor-driving mutations has been disappointing. Dr. Hammarstrm, Senior Scientist and co-founder of the Chemical Biology Consortium Sweden at Karolinska Institutet, will share about his groups work in developing a novel method for identifying treatments for GBM.

Please help us out :
Will you offer us a hand? Every gift, regardless of size, fuels our future.
Your critical contribution enables us to maintain our independence from shareholders or wealthy owners, allowing us to keep up reporting without bias. It means we can continue to make Jewish Business News available to everyone.
You can support us for as little as $1 via PayPal at office@jewishbusinessnews.com.
Thank you.

Assuming that mutations in GBM lead to acquired cellular functions not only involved in the tumorigenic process, the group performed an unbiased phenotypic screen of a small molecule library on patient-derived, tumor-initiating GBM cells to identify specific cellular responses which could be selectively modulated by small molecules. An identified quinoline derivative and subsequent synthesized analogs (termed Vacquinols) reliably compromised GBM viability through a non-apoptotic mechanism associated with massive induction of macropinocytosis which was not induced in other cell types investigated. Though the primary pharmacological target remains unknown, shRNA-induced Vacquinol-1-resistant mutants revealed the MAP-kinase MKK4 as a critical signaling node. Vacquinol-1 displays excellent in vitro and in vivo pharmacokinetics with good exposure into the CNS. Oral administration in a mouse xenograft model of GBM dramatically reduces tumor size, attenuates disease progression and significantly prolongs survival.

Dr. Hammarstrm will describe current efforts focused on further advancing the Vacquinol series towards clinical development, approaches towards identification of the primary target(s) of Vacquinol-1, and elucidation of the underlying cellular pathways involved in the response.

For more information on Dr. Hammarstrms presentation, as well as the conference, please visit www.gtcbio.com/cbast2014 .

Company Contact Information
Kristen Starkey
http://www.gtcbio.com/
(626) 256-6405
 
Read Full Article
Advertisement. Scroll to continue reading.

Newsletter



Advertisement

You May Also Like

World News

In the 15th Nov 2015 edition of Israel’s good news, the highlights include:   ·         A new Israeli treatment brings hope to relapsed leukemia...

Entertainment

The Movie The Professional is what made Natalie Portman a Lolita.

Travel

After two decades without a rating system in Israel, at the end of 2012 an international tender for hotel rating was published.  Invited to place bids...

VC, Investments

You may not become a millionaire, but there is a lot to learn from George Soros.