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CanFite Wins U.S. Patent For The Reduction Of Intraocular Pressure

Can-Fite logo

Can-Fite BioPharma Ltd. (TASE: CFBI), (OTCQB: CANFY) and its subsidiary, OphthaliX Inc. (OTCQB: OPLI), jointly announced today that the U.S. Patent and Trademark Office granted a U.S. patent which bears the Patent No. 8, 557, 790 and is titled “A3 Adenosine receptor agonists for the reduction of intraocular pressure”.

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Increased intraocular pressure (“IOP”) is the most important and only modifiable risk factor for glaucoma. This patent was granted to Can-Fite and relates to the use of the drug candidate CF101. Pursuant to a license agreement between Can-Fite and OphthaliX’s wholly owned subsidiary, EyeFite Ltd., OphthaliX has the exclusive rights for the use and development of CF101 for the reduction of IOP in the United States until 2030.

The discovery that CF101 may be used for the treatment of glaucoma is the result of serendipitous data derived from a Phase II study of CF101 in patients with dry eye syndrome. A reduction in IOP in such patients’ eyes indicated that CF101 could potentially treat glaucoma. In addition, during the ARVO 2013 Annual Meeting in Seattle, Washington, Professor M. Francesca Cordeiro, a Professor of Glaucoma & Retinal Neurodegeneration Studies from the University College of London and Imperial College in London, presented new data, generated by independent studies unrelated to Can-Fite or OphthaliX, validating the utilization and efficacy of A3 adenosine receptor agonists for lowering IOP and for the treatment of glaucoma. Based on the foregoing, OphthaliX is currently conducting a Phase II study with CF101 for the treatment of glaucoma and related syndromes of ocular hypertension in Israel and Europe.

Prof. Pnina Fishman, Chief Executive Officer of Can-Fite and Chairman of the Board of Directors of OphthaliX, said today: “We are very pleased with the grant of the U.S. patent for reducing IOP. We believe that such patent will enable us to further develop CF101 in order to potentially prove its efficacy in the treatment of glaucoma and ocular hypertension, potentially bringing relief to millions of patients suffering from such conditions in the future.”


About Glaucoma and IOP

Glaucoma is an eye disease in which the optic nerve is damaged. This optic nerve damage involves loss of retinal ganglion cells, or neurons located near the inner surface of the retina, in a characteristic pattern. There are many different subtypes of glaucoma, but each can be considered to be a type of optic neuropathy. Increased IOP is the most important and only modifiable risk factor for glaucoma. Untreated glaucoma can lead to permanent damage of the optic nerve and resultant visual field loss, which over time can progress to blindness.


About CF101

CF101, an A3 adenosine receptor agonist, is a novel, first in class, small molecule, orally bioavailable drug which demonstrated efficacy and an excellent safety profile in Phase II clinical studies. Through a service arrangement with its parent, Can-Fite, OphthaliX currently develops CF101 for the treatment of ophthalmic indications, including dry eye syndrome (Phase III), glaucoma (Phase II) and uveitis (initiating Phase II). CF101 is also developed by Can-Fite for the treatment of autoimmune inflammatory diseases, including, but not limited to, rheumatoid arthritis (Phase IIb) and psoriasis (Phase II/III).



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