A team of Israeli scientists at Bar-Ilan University conducted a study that shows that microbiome changes – specifically gut microbiomes – in the body are linked to Autism Spectrum Disorder (ASD). This is one of several such breakthroughs related to Autism made by Israelis in recent times.
The gut microbiome is a complex community of trillions of microorganisms, mainly bacteria, that live in your digestive tract. These tiny microbes play a crucial role in many aspects of your health, from digestion and nutrient absorption to immune function and even mood.
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The Israeli researchers analyzed the diversity of the gut microbiome on an Israeli cohort of 96 individuals diagnosed with ASD and 42 neurotypical individuals. Their findings, recently published in the journal npj Biofilms and Microbiomes, point to significant differences in both alpha and beta diversity in individuals with ASD, and identify specific types of bacteria that are found at higher abundance in individuals with autism.
The key discoveries include an unexpected increase in alpha diversity, a measure of microbial diversity, and a notable rise in the relative abundance of the phylum Bacteriodetes and the genus Bacteroides in individuals with ASD. Traditionally, decreased alpha diversity has been associated with compromised health in various conditions. However, the increased alpha diversity observed in the ASD cohort challenges prevailing notions, especially considering its potential connection to neurological diseases. Bacteroides, normally found in the human gut microbiome, may have a disadvantageous impact on health when increased in abundance.
To investigate the potential functional consequences of these microbiome changes, the researchers conducted experiments involving newborn mice. Mice treated with Bacteroides fragilis at birth exhibited social behavior dysfunction, increased repetitive behaviors, and gene expression dysregulation.
“Our research suggests that an overabundance of Bacteroides, particularly in early life, may have functional consequences for individuals with ASD. This sheds new light on the complex interplay between the microbiome and neurodevelopment in individuals with ASD,” said the study’s lead researcher, Prof. Evan Elliott, of Bar-Ilan University’s Azrieli Faculty of Medicine. The study was conducted in collaboration with Prof. Omry Koren, a microbiome expert at the Azrieli Faculty.
The implications of this research extend beyond the laboratory, offering potential avenues for further exploration into the long-term effects of microbial interventions during early developmental stages and their implications for brain development.
As for other Israeli studies on Autism, ast May researchers from the Hebrew University of Jerusalem established a direct link between nitric oxide (NO) levels in the brain and autism. The study revealed a compelling association between increased levels of NO in the brain and the manifestation of autism symptoms, uncovering a previously unknown mechanism related to the disorder. Conversely, when NO levels were purposefully and controlled reduced in murine models of autism, the indicators and behaviors associated with autism also decreased.
Autism Spectrum Disorder (ASD), a neurodevelopmental condition characterized by decreased social communication and repetitive behaviors, has long intrigued scientists seeking to unravel its underlying mechanisms. Researchers from the Azrieli Faculty of Medicine of Bar-Ilan University have now identified a potential link between ASD and the composition of the gut microbiome.
