Connect with us

Hi, what are you looking for?

Jewish Business News

Syndicated

General Hospital Reveals Fourteen Years of HIV Functional Cure: The Case of the ‘Toulon Patient’

A man infected by HIV-1 in 1998 was treated at the time of acute infection with 4 antiretrovirals during 2 years and is now still in remission.

A man infected by HIV-1 in 1998 was treated at the time of acute infection with 4 antiretrovirals during 2 years and is now still in remission.

Online PR News – 05-August-2014 – There is only one man cured from HIV in the world, the “Berlin” patient: the only case of HIV cure, because in every infected patient we observe a HIV persistence. To reach this cure he received a non-scalable procedure with bone marrow transplant due to acute leukemia from a special donor. His life was in danger, so the risks were below the benefits.

Dr Alain Lafeuillade, MD, PhD, from Toulon General Hospital, France, reports another case where life was not in danger and the procedure used can be applied to anyone in the world.

Please help us out :
Will you offer us a hand? Every gift, regardless of size, fuels our future.
Your critical contribution enables us to maintain our independence from shareholders or wealthy owners, allowing us to keep up reporting without bias. It means we can continue to make Jewish Business News available to everyone.
You can support us for as little as $1 via PayPal at [email protected].
Thank you.

In 1998 Dr Lafeuillade diagnosed in Toulon, France, a case of acute HIV infection in a man who practiced unprotected receptive anal sex. His Western blot HIV serology was undetermined but plasma viral load was high. The Doctor immediately started a combination of 4 antiretrovirals (d4T, ddI, Saquinavir, Ritonavir at antiviral doses) with one week a month Hydrea, an anti-cancer drug, and 2 series of IL-2 injections, an immunostimulant, during 2 years. This combination was prescribed in the context of a pilot trial initiated at General Hospital with all the legal green lights.

In 2000 when all the medications were stopped Dr Lafeuillade did not observed a rebound in viremia. In fact, in 2003 when the test was performed with increased sensitivity, HIV was undetectable in blood, below 1 copy/ml. Over the years, proviral DNA in circulating lymphocytes became also undetectable. Last week, the patient had a rectal examination with routine biopsies and no HIV RNA or DNA was detectable in lymphoid cells despite the fact that gut lymphocytes are a major HIV reservoir. The patient CD4 cell count (measure of immunity) is normal with a CD4/CD8 ratio constantly above 1. There is no ongoing inflammation measured in plasma. HIV is also undetectable in his sperm.

Although this patient is still HIV positive (in terms of antibodies) and has probably minor traces of provirus somewhere, and HIV eradication was not achieved, The Infectious Diseases team of General Hospital can declare that he his functionally cured from HIV for 14 years now. He had no HLA marker predisposing him to evolve as an “Elite Controller”.

This is the first report of a long-term HIV functional cure with intense HIV reservoirs decrease in a patient in good condition.

Doctor Lafeuillade is also an associate Professor at the University of Maryland, USA, where he works under the supervision of Professor Robert Gallo, Director of the Institute of Human Virology (www.ihv.org) and the one who discovered HIV and its role in the development of AIDS.

This approach is able to produce a revolution for the 34 millions of individuals infected with HIV worldwide, by bringing them HIV cure.

Quote:

“We have functionnally cured HIV in this patient for 14 years! Dr Lafeuillade said.”

Company Contact Information
Lafeuillade Alain
http://www.hiv-persistence.com
33494145084
 

Newsletter



Advertisement

You May Also Like

World News

In the 15th Nov 2015 edition of Israel’s good news, the highlights include:   ·         A new Israeli treatment brings hope to relapsed leukemia...

Entertainment

The Movie The Professional is what made Natalie Portman a Lolita.

Travel

After two decades without a rating system in Israel, at the end of 2012 an international tender for hotel rating was published.  Invited to place bids...

VC, Investments

You may not become a millionaire, but there is a lot to learn from George Soros.